Diagnosing lung cancer in exhaled breath using gold nanoparticles

Nature Nanotechnology
Published online: 30 August 2009 | doi:10.1038/nnano.2009.235

Diagnosing lung cancer in exhaled breath using gold nanoparticles
Gang Peng1,2, Ulrike Tisch1,2, Orna Adams1, Meggie Hakim1, Nisrean Shehada1, Yoav Y. Broza1, Salem Billan3, Roxolyana Abdah-Bortnyak3, Abraham Kuten3,4 & Hossam Haick1,2

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Abstract: Conventional diagnostic methods for lung cancer1, 2 are unsuitable for widespread screening2, 3 because they are expensive and occasionally miss tumours. Gas chromatography/mass spectrometry studies have shown that several volatile organic compounds, which normally appear at levels of 1–20 ppb in healthy human breath, are elevated to levels between 10 and 100 ppb in lung cancer patients4, 5, 6. Here we show that an array of sensors based on gold nanoparticles can rapidly distinguish the breath of lung cancer patients from the breath of healthy individuals in an atmosphere of high humidity. In combination with solid-phase microextraction7, gas chromatography/mass spectrometry was used to identify 42 volatile organic compounds that represent lung cancer biomarkers. Four of these were used to train and optimize the sensors, demonstrating good agreement between patient and simulated breath samples. Our results show that sensors based on gold nanoparticles could form the basis of an inexpensive and non-invasive diagnostic tool for lung cancer.

1.Department of Chemical Engineering, Technion – Israel Institute of Technology, Haifa 32000, Israel
2.Russell Barrie Nanotechnology Institute, Technion – Israel Institute of Technology, Haifa 32000, Israel
3.Oncology Division, Rambam Health Care Campus, Haifa 31096, Israel
4.Bruce Rappaport Faculty of Medicine, Technion – Israel Institute of Technology, Haifa 31096, Israel

Correspondence to: Hossam Haick1,2
e-mail: hhossam@technion.ac.il

source:http://www.nature.com/nnano/journal/vaop/ncurrent/abs/nnano.2009.235.html

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~ by vascoteixeira on August 31, 2009.

 
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